Abstract
Mitochondrial DNA depletion induces innate immune dysfunction rescued by IFN-γ
Highlights
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
We studied the effects of reducing mitochondrial DNA (mtDNA) levels on immune function in THP-1 cells, a human monocyte cell line
Using 2 independent methods to induce mtDNA depletion, we show that mtDNA depletion can reversibly impair innate immune responses in THP-1 cells
Summary
THP-1 cells (TIB-202; ATCC, Manassas, Va) were maintained at a concentration of
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