Abstract

The age-related increase in aneuploidy has been observed in both humans and mice. Therefore, mice have the potential to be a useful model system to study the origins, etiology, and mechanisms of human aneuploidy and serve as a system to develop new therapeutic strategies. To further establish relevance to this model system, this study aims to validate a method capable of mitochondrial (mt)DNA quantitation in the mouse blastocyst and evaluate putative association with aneuploidy.

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