Mitochondrial Complex I Deficiency among Egyptian Pediatric Patients with Steroid-Resistant Nephrotic Syndrome.

Doaa M Abdou,Mohamed Abdulhay,Sara El Khateeb,Abdelaal Mohamed

doi:10.1155/2021/6645373

Abstract

Results Positive consanguinity was a remarkable finding in 44 patients among the SRNS group (73%), compared with 33 patients among the SSNS group (55%). Complex I activity was significantly lower in the SRNS group (0.2657 ± 0.1831 nmol/ml/min), than in the SSNS group (0.4773 ± 0.1290 nmol/ml/min) (p < 0.001). There was a significant positive correlation between complex I activity and the heaviness of proteinuria among the SRNS group (r 0.344, p < 0.001). There were statistically significant differences in serum C3 and C4 levels between both groups (p < 0.001, 0.053, respectively). Conclusion Mitochondrial complex I deficiency in patients who have a nephrotic syndrome complaint may play a role in their responsiveness to steroid therapy and the development of SRNS and even the prognosis of their illness.

Highlights

Nephrotic syndrome (NS) is a clinical condition characterized by massive proteinuria (>3 gm urinary proteins), hypoalbuminemia, edema, and hyperlipidemia [1]
Results is study included 120 patients divided into two groups, group I represented steroid-resistant nephrotic syndrome (SRNS) (60 patients) and group II represented the sensitive nephrotic syndrome (SSNS) (60 patients). ere was a statistical significant difference between both groups including 53 females (44.2%) and 76 males (55.8%). ere was a statistically significant difference of the age at the time of diagnosis between the SRNS group (Mean ± standard deviation (SD) 7 ± SD years) compared with the SSNS (Mean ± SD 6.5 ± 2.8 years) (p < 0.001)
E main pathological findings were focal segmental glomerulosclerosis (FSGS) in 44 (73.3%) patients of SRNS, and 40 patients of SSNS (66.7%), followed by minimal changes glomerulonephritis (MCGN) with 8 patients (13.3%) in group I and 16 patients (26.6%) in group II; nonspecific pathological findings were detected in 7 patients (11.7%) of group I, and 4 patients (6.7%) of group II

Summary

Introduction

Nephrotic syndrome (NS) is a clinical condition characterized by massive proteinuria (>3 gm urinary proteins), hypoalbuminemia, edema, and hyperlipidemia [1]. Ere was a statistically significant difference of the age at the time of diagnosis between the SRNS group (Mean ± SD 7 ± SD years) compared with the SSNS (Mean ± SD 6.5 ± 2.8 years) (p < 0.001).

Results

Conclusion