Abstract
Variations in glutamic dehydrogenase and isocitric dehydrogenase levels have been studied in mitochondria, soluble phase of cytoplasm and blood plasma in mouse hepatitis by MHV-3 virus. In an early stage of the disease a partial alteration of mitochondria was observed as shown by increased solubilization of isocitric dehydrogenase following freezing and thawing as well as aging of mitochondria. In later stages of the disease, mitochondrial enzymes were released from mitochondria into the soluble phase of cytoplasm and from this to the blood stream. The data indicate that the glutamic dehydrogenase is less easily released into the blood stream, as shown by its increase in the soluble phase of cytoplasm in advanced stages of liver cell lesion.
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