Abstract
Mitochondria play important roles in the regulation of apoptosis, Ca2+ homeostatis and ATP generation. Mitochondrial respiration has been linked with fertilisation and embryo development1,2. Despite recent advances in ART methods of cryopreservation, oocyte transcriptome and mitochondria function remain susceptible to cryopreservation-related perturbations which may affect treatment outcomes in ART couples and those who require fertility preservation following cancer diagnosis. With established evidence from the Developmental Origins of Health and Disease (DOHaD) hypothesis, and increasing application of cryopreservation procedures, the wider impact of environmental exposures on oocyte mitochondria function and molecular integrity in ART procedures is yet to be fully evaluated3,4,5.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
