Mitochondrial β-Carotene 9′,10′ Oxygenase Modulates Prostate Cancer Growth via NF-κB Inhibition: A Lycopene-Independent Function

Xiaoming Gong,Susan Zaripheh,Doris Wiener,Raju Marisiddaiah,Lewis P Rubin

doi:10.1158/1541-7786.mcr-16-0075

Abstract

This study identifies BCO2 as a tumor suppressor in prostate cancer. BCO2-mediated inhibition of NF-κB signaling implies BCO2 status is important in prostate cancer progression. Mol Cancer Res; 14(10); 966-75. ©2016 AACR.

Highlights

Prostate cancer is the most common noncutaneous cancer among men and second leading cause of cancer-related death among men in the United States [1]
BCO2 expression is decreased in human prostate cancer BCO2 is expressed in human normal prostate [21]
To determine whether BCO2 is expressed in prostate cancer tissue, we first compared BCO2 protein lysates isolated from normal prostate tissues, benign prostatic hyperplasia (BPH), and prostate cancer tissues by Western blot analysis using an antibody specific for human anti-BCO2 antibody (Fig. 1A)

Summary

Introduction

Prostate cancer is the most common noncutaneous cancer among men and second leading cause of cancer-related death among men in the United States [1]. A high occurrence rate, slow tumor growth, and long latency to clinically significant disease suggest prostate cancer may be especially amenable to environmental (including nutritional) preventive and therapeutic interventions. Epidemiologic studies and clinical trials have shown an inverse relationship exists between dietary lycopene intake and prostate cancer. A non-pro-vitamin A carotenoid found in tomatoes, tomato-based products, and other foods, is the predominant carotenoid accumulated in prostate tissue [5]. Men who consume tomatoes and tomato-based products have a significantly lower risk of prostate cancer [6]. These putative effects have been attributed, in part, to lycopene's potent antioxidant properties [7], but the relevance of this mechanism has been challenged [8]

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Results

Conclusion