Abstract
AbstractOxidovanadium(IV) complexes [VO(py‐aebmz)(B)]Cl (1, 2) and [VO(napth‐py‐aebmz)(cur)]Cl [3; py‐aebmz = 2‐(1H‐benzimidazol‐2‐yl)‐N‐(pyridin‐2‐ylmethylene)ethanamine, HB = acetylacetone (Hacac, 1) and curcumin (Hcur, 2), napth‐py‐aebmz = naphthalimide conjugated to py‐aebmz ] have been prepared, characterized and their photoinduced DNA cleavage activities and photocytotoxicities studied. Complexes 1–3 each exhibited an irreversible cyclic voltammetric response of the VIV/VIII redox couple at around –0.85 V versus SCE in dmf/0.1 M tbap. The complexes showed DNA photocleavage activity in visible light of 454, 530 and 647 nm through hydroxyl radical and singlet oxygen pathways. Fluorescence microscopy data suggest mitochondrial localization of complex 3 bearing a naphthalimide with a two‐fold increase in photocytotoxicity in HaCaT cells with an IC50 value of 6.3 μM and a three‐fold increase in MCF‐7 cells with an IC50 of 5.4 μM compared with complex 2. Both 2 and 3 were non‐toxic in the dark.
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