Abstract
Objective: The central role of mitochondria is energy metabolism and ATP production, and recent work has revealed the importance of mitochondrial dysfunction in a number of cellular processes, including cell death. There is little information about the role of mitochondria in calcium regulation and signaling in gastrointestinal tissues. To understand the role of mitochondria in intracellular calcium signaling in the enteric nervous system, we studied the relationship of the cytosolic calcium concentration ([Ca2+] c) and mitochondrial matrix calcium concentration ([Ca2+] m), and the effect of mitochondrial dysfunction on the calcium signal in guinea pig enteric neurons.
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