Abstract
The environmental pollution of polystyrene microplastics (PS-MPs) is a raising global concern as it imposes adverse effects on the health of organisms. Herbacetin (HBN) is a natural flavone with diverse biological activities. Therefore, the study was intended to assess the curative role of HBN against PS-MPs provoked hepatic damage. 48 rats were divided into 4 groups, control, PS-MPs-intoxicated (0.01 mg/kg), PS-MPs + HBN co-treated (0.01 mg/kg + 40 mg/kg) and HBN only treated (40 mg/kg) group. The experiment was conducted for 30 day. PS-MPs administration lowered the expressions of Nrf-2 and anti-oxidants genes, although increased the Keap-1 expression. It also lessened the activities of superoxide dismutase (SOD), glutathione reductase (GSR), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and heme oxygenase-1 (HO-1) and glutathione (GSH) level, besides elevating the levels of MDA and ROS. Additionally, PS-MPs augmented alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine transaminase (ALT) levels. Furthermore, there was an upsurge in the levels of inflammatory indices in PS-MPs treated group. PS-MPs also upregulated Caspase-3 and Bax expression, besides suppressed Bcl-2 expression. Nevertheless, HBN therapy amended all the impairments due to its anti-apoptotic, anti-oxidant and anti-inflammatory, hepatoprotective nature. So, it might be anticipated that HBN can applied as a drug to cure hepatic toxicity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
