Abstract
The aim of present project was to determine the harmful effects of CdCl2 on epididymis of adult mice (Mus musculus). Histopathological changes in epididymis of mice treated with 50ppm of CdCl2 were studied in this research work. Moreover, remedial effects of Jambul fruit extract were also studied. Study was conducted on 30 male albino mice divided into three groups (n=10) as follows; {(a) Control (C); (untreated); (b) CdCl2 {50ppm CdCl2 as drinking water (15 days) and for natural recovery CdCl2 free water (7days); (c) CdCl2+Jambul extract (CdCl2+J) 50ppm CdCl2 in drinking water for 15 days followed by 0.2mLJambul extract (7days)}. All animals were dissected on day 21st for surgical removal of epididymis. The results revealed that mean tubular cross-sectional area of caput, corpus and cauda epididymis was significantly increased in CdCl2 treated group compared to Control and Cd+J treated groups. A single peritoneal administration of soluble cadmium causes an acute hemorrhagic reaction in proximal end of caput epididymis. The lining epithelium of the proximal caput was atrophied, tubules were dilated and spermatozoa within the lumen were disintegrated.
Highlights
Cadmium (Cd) is a toxic heavy metal that occurs in natural environment and as a pollutant emanating from industrial and agricultural sources (Jarup and Akesson, 2009)
The results revealed that mean tubular crosssectional area of caput, corpus and cauda epididymis was significantly increased in CdCl2 treated group compared to Control and Cd+J treated groups
1-General Observations: At the time of dissection various morphological changes were observed in only Cdcl2treated group, which are thick and blackish blood with slow rate of flow, very less amount of fats was noticed around viscera, color of liver was pale and having white spots, spleen larger in size and lungs were reduced compared to control, testes were smaller in size and attached with scrotum and epididymis was highly reduced in size. 2-Body Weight: Initial and final body weight of Control, CdCl2, and Cd+J treated groups were recorded CdCl2 treated groups resulted in highly significant (P
Summary
Cadmium (Cd) is a toxic heavy metal that occurs in natural environment and as a pollutant emanating from industrial and agricultural sources (Jarup and Akesson, 2009). Traces amount of Cadmium is present in water as well as in plants and animals (Min et al, 2002). Cadmium occurs in rock erosion and abrasion, volcanic eruptions (Jarup et al, 2000), fossil fuels, non-ferrous mining and metal industries (Friberg et al, 1986). The compound has varying degrees of solubility, absorption, and toxicity (Falks et al, 1990).In animal studies, various effects of cadmium on male reproductive system were reported as an accumulation of cadmium in reproductive organs, decreased testicular, epididymal, vas deferens and accessory glands weight, ischemia-induced necrosis in testes, accumulation of metal in spermatogenic cells, reduction in the number of germ and sertoli cells along with decreased androgens and gonadotropins (Shimada et al, 2009; Ozdemir and Dursun, 2009).Syzygium cumini (Jambul) is a perennial tropical tree of family Myrtaceae (Lanjewar et al, 2018).
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