Mitigating Cognitive Deficits in Down Syndrome by Managing Microglia Activation

Patricia R Shaw,Tarik F Haydar

doi:10.1016/j.neuron.2020.11.017

Mitigating Cognitive Deficits in Down Syndrome by Managing Microglia Activation

Patricia R Shaw, Tarik F Haydar

Open Access

https://doi.org/10.1016/j.neuron.2020.11.017

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Journal: Neuron	Publication Date: Dec 1, 2020
Citations: 1	License type: publisher-specific-oa

Affiliation: Boston University, Children's National

#Deficits In Down Syndrome #Dysfunction In Down Syndrome + Show 8 more

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Abstract

In this issue of Neuron, the comprehensive and multidisciplinary results from Pinto etal. (2020) point to novel and widespread microglial dysfunction in Down syndrome that results in impaired cognitive ability. A common pharmaceutical (acetaminophen) is shown to offset these effects in mouse models.

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