Misoprostol and dinoprostone therapy for labor induction: a Doppler comparison of uterine and fetal hemodynamic effects

Abstract

Objective: To compare the effect of misoprostol (PGE1) versus dinoprostone (PGE2) on blood flow in uteroplacental circulation during labor induction. Study design: Eighty-four women with indications for induction of labor were assigned to receive either misoprostol 50μg per vagina every 4h as needed or 0.5mg doses of dinoprostone given intra-cervically every 6h by means of a randomization table generated by computer. Doppler velocimetry of umbilical, uterine and arcuate arteries was performed immediately before and 2–3h after the administration of misoprostol or dinoprostone. The SAS system was used to perform statistical analysis. Results: There were no significant changes of pulsatility index (PI), resistance index (RI) and systolic/diastolic (S/D) ratio in umbilical arteries after both prostaglandin compounds. Vaginal application of misoprostol significantly increased all ratios in arcuate artery and S/D ratio in uterine artery. Intra-cervically dinoprostone significantly increased PI, RI and S/D ratio in arcuate and uterine arteries. Conclusions: Our results indicate that vaginal misoprostol and cervical dinoprostone administration increases uteroplacental resistance but does not affect umbilical blood flow. Misoprostol would be as safe and effective agent as dinoprostone for cervical ripening and labor induction.