Mismatch negativity reveals plasticity in cortical dynamics after 1-hour of auditory training exercises

Abstract

BackgroundImpaired sensory processing contributes to deficits in cognitive and psychosocial functioning in individuals with schizophrenia (SZ). Mismatch Negativity (MMN), an event-related potential (ERP) index of sensory discrimination associated with cognitive and psychosocial functioning, is a candidate biomarker of auditory discrimination and thus possibly of changes following auditory-based Targeted Cognitive Training (TCT). Here we evaluated the acute effect of TCT on cortical processes supporting auditory discrimination. MethodsMMN was assessed in 28 SZ outpatients before and after a single 1-hour (hr) session of “Sound Sweeps,” a pitch discrimination task that is a component of the TCT suite of exercises. Independent component (IC) analysis was applied to decompose 64-channel scalp-recorded electroencephalogram (EEG) activity into spatiotemporally stationary sources and their activities. ICs from all patients were pooled to find commonalities in their cortical locations. IC cluster-mean ERPs were evaluated to determine the clusters contributing to the (140–200 ms) MMN difference between responses to deviant and standard tone stimuli respectively. ResultsTwo frontal IC clusters centered in orbitofrontal cortex (OFC) and anterior cingulate cortex (ACC) accounted for >77% of MMN variance across all scalp channels. After 1-hr auditory training, significant suppression of ACC cluster contributions was detected, whereas the OFC cluster contribution was unchanged. ConclusionsPrior to TCT, the MMN response was dominated by EEG effective sources in or near OFC and ACC. However, after 1-hr of auditory-based TCT, a significant attenuation of ACC was observed, whereas OFC contribution to MMN persisted. The present findings support further trials designed to test whether training-related MMN plasticity in the ACC after 1-hr may predict individual patient response to a full course of TCT.