Abstract
The aim was to evaluate the mismatch negativity (MMN) component, a correlate of the automatic detection of changes in the acoustic environment, in healthy adults, and adults with amnestic mild cognitive impairment (aMCI). Forty-three aMCI subjects and 43 healthy Chinese older adults were arranged into experimental group and control group, respectively. Their MMN amplitude and latency were measured at the FZ, FCZ, and CZ electrode sites under a passive auditory oddball task. The results showed that the latencies obtained from the FZ, FCZ, and CZ electrode sites were significantly longer in the aMCI adults than in the control adults (P < 0.01) while there were no significant differences in MMN amplitude between two groups (P > 0.05). The MMN latency was found to be a sensitive and specific biomarker of aMCI.
Highlights
Mild cognitive impairment (MCI) refers to the gray zone between the cognitive changes of normal aging and very early dementia (Grundman et al, 2004a; Stephan et al, 2013)
The results showed that the latencies obtained from the FZ, FCZ, and CZ electrode sites were significantly longer in the amnestic mild cognitive impairment (aMCI) adults than in the control adults (P < 0.01) while there were no significant differences in MMN amplitude between two groups (P > 0.05)
The aims of the present study were as follows: (1) to determine any differences in MMN parameters between healthy adults and adults with aMCI in Chinese rural population; (2) to evaluate whether such differences between healthy adults and adults with aMCI are affected by electrode sites, by considering three electrode sites (FZ, FCZ, CZ); (3) to evaluate whether MMN changes associated with aMCI are sensitive and specific biomarkers of this syndrome
Summary
Mild cognitive impairment (MCI) refers to the gray zone between the cognitive changes of normal aging and very early dementia (Grundman et al, 2004a; Stephan et al, 2013). One large cross-sectional study (Jia et al, 2014) conducted in China, using a multistage cluster sampling design, included a total of 10,276 community residents (6096 urban, 4180 rural) aged 65 years or older, found a prevalence rate of 20.8% for MCI in Chinese elders. By the year 2050, those numbers are projected to double with the actual number of people over age 65 projected to be almost 300 million, at which point the population of older persons will be accounted for almost 22% of the Chinese population (2014). As the high prevalence of MCI in Chinese rural elders and the rate at which the Chinese population is aging has accelerated, we can forecast that there would be a huge population (about 35.1 million) of elders with MCI by the year 2050 in the rural of China. The MCI patients in rural areas can hardly get medical help
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