Mismatch negativity abnormality in traumatic brain injury without macroscopic lesions on conventional MRI

Abstract

Traumatic brain injury (TBI) causes damage through complex pathophysiological mechanisms. Deficits related to traumatic axonal injury persist in a subset of patients with no macroscopic lesions on conventional MRI. We examined two event-related brain potentials, mismatch negativity (MMN) and P3a, to identify possible electrophysiological anomalies in this subset of TBI patients in comparison with TBI patients with focal abnormalities on MRI/computed tomography and healthy controls. Each group consisted of 10 individuals. A passive oddball paradigm, in which the individuals were instructed to ignore auditory stimuli while watching a silent movie, consisted of non-native speech sounds presented in a random order. Patients with no discernible lesions on conventional MRI showed a significantly augmented amplitude of the brain's involuntary change-detection response MMN, relative to that of the two other groups. In patients with focal neuroradiological abnormalities, this MMN anomaly was not found, whereas the subsequent orientation-related P3a response was significantly enlarged when compared with that of the controls. The present findings demonstrate that MMN is indicative of a functional abnormality in the mechanisms of involuntary attention in chronic TBI patients with normal conventional MRI findings, indexing their increased distractibility associated with the traumatically-induced loss of neural integrity.