Miscarriage rate comparison of PGS cycles performed with array comparative genome hybridization (aCGH) and next generation sequencing (NGS)

Abstract

hr-NGS detects mosaicism in about 20% of trophectoderm biopsies while aCGH in about 4%. Mosaic embryos are at a higher risk of miscarriage, have lower implantation potential; however some may result in a live birth. The objective of this study is to determine if the rate of miscarriage is reduced in PGS cycles by transferring non-mosaic embryos selected by NGS compared to cycles performed by aCGH.