Abstract
The search continues for an ideal animal model of human idiopathic interstitial pulmonary fibrosis, which has included a broad spectrum of interstitial lung diseases depending at least partly upon stages in the development of the disease. Ten years ago, Carrington 1 Carrington CB Organizing interstitial pneumonia. Definition of the lesion and attempts to devise an experimental model. Yale J Biol Med. 1968; 40: 352 PubMed Google Scholar proposed the following as requirements for an animal model: anatomic changes characterized by a mixed cellular exudate in the interstitium, protein exudate with or without cells in the air spaces, proliferation of lining epithelium, gradual progression to fibrosis with continuing activity and eventual honeycombing, and diffuse distribution with the possibility of skip zones.
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