MIS-C A RETROSPECTIVE OBSERVATIONAL STUDY FROM TERTIARY CARE CENTERS OF PURVANCHAL AREA OF EASTERN U.P. AND ADJACENT SOUTH BIHAR.

Abstract

Objective:We are describing the temporal prole of 19 cases of MIS-C including demographic, clinical and laboratory ndings along with the treatment and outcomes .We also studied the response to various available treatment modalities for MIS-C. Method: This was a retrospective observational study carried out at a tertiary care center . Children satisfying WHO MIS-C criteria admitted from Apr 2021 to Aug 2021 to PICU were included. The clinical prole, treatment, laboratory parameters and outcomes in all 19 critically ill children diagnosed with MIS-C were analyzed from Apr 2021 to Aug 2021. Results: The study population in this study included 19 patients with MIS-C . All 19 children had fever,15 of them had gastrointestinal features. Hypotension was observed in 12 cases. Eye changes in the form of conjunctival congestion, conjunctivitis,& conjunctival hemorrhage was observed in 14 children. Most of them were treated with steroids alone, Few of them required steroids as well as IVIg. There was no treatment failure observed in any of the cases. There was a gradual reduction of the CRP by day 3 in most of the cases.. Follow up studies have not revealed any abnormality on echocardiography Conclusion:Steroids were found to be equally effective & were the rst line of management in all the cases. IVIG was used in cases which were subjected to mechanical ventilation in children with SARS-CoV-2 related MIS-C. There was no mortality in this group