Abstract
miRNAs are involved in the generation and progression of musculoskeletal pain, a condition that causes significant clinical, economicand social burden. In runners, the presence of musculoskeletal pain related to aninflammatory state or ongoing underlying tissue damage may result in poor training ability and performance. This study aimsto evaluate the association between circulating and salivary miRNAs and pain in runners with and without musculoskeletal painand to observe whether dysregulated miRNAs candistinguish between responders and nonresponders to a kinesiological intervention. The possible correlation between these miRNAs and inflammatory molecules, stress parameters and individual or behavioral characteristics will beevaluated. Finally, in silico analysis will be used to characterize miRNAs function. Ethics approval was obtained.
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