Abstract
Background: Subcutaneous immunotherapy (SCIT) is widely used in the treatment of allergic rhinitis (AR). This study aimed to determine the expression of 48 miRNAs in patients with AR undergoing grass pollen SCIT and investigate relations with clinical outcomes. Methodology: Expression of selected miRNAs was determined using RT-PCR in thefull blood of 16 patients with AR and sevenhealthy controls. Results:miR-136, miR-208 and miR-190 were upregulated in theAR group. After 6 months of SCIT, significant downregulation of some proinflammatory miRNAs and upregulation of several miRNAs regulating Th1/Th2 balancewerefound. No differences were found between good and poor responders. Conclusion:miRNAs may play a regulatory role in SCIT, leading to tolerance induction.
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