Abstract
Recent advancements have revealed a complex post-transcriptional regulatory network in humans involving miRNAs. However, the contribution of miRNAs to human evolution, especially interindividual variation associated with miRNAs, is only beginning to be studied. In this article, we illustrate the extent of variation in miRNA-mediated post-transcriptional regulation in humans. Based on evidence from recent studies, we argue that the evolution of post-transcriptional control may be adaptive, and that it not only complements the primary transcriptional regulation by transcription factors (TFs), but also diversifies gene expression phenotypes, thereby generating genetic novelty on which natural selection subsequently acts. Given that current evolutionary analyses and genotype-phenotype mapping are primarily focused on protein-coding genes and TF-mediated regulations, comprehensive examination of post-transcriptional variations should be included in future studies to add a new dimension to understanding of human phenotypic evolution.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
