MiRNA-423 rs6505162and miRNA-6811 rs2292879SNP AssociatedwithLung Cancer in Hainan, China.

Abstract

MicroRNAs (miRNAs) are known to exert significant influence on various physiological processes and diseases, including cancers. The primary objective of this present study was to examine the impact of eightsingle nucleotide polymorphisms(SNPs)in miRNA on the susceptibility to lung cancer (LC) within the Chinese Southernpopulation. Thegenotypes of these eight polymorphisms weredeterminedin132 LC patients and 214cancer-free controls. In overall analyses, GG genotype of miRNA-6811 rs2292879 polymorphismwas significantly correlated with increased risk ofLC (GG vs. AA,adjusted OR = 5.10, 95% CI = 1.02 ~ 25.43, P= 0.047), yet the genotype frequenciesof rs2292879SNP in controlsdid notmet the Hardy-Weinberg equilibrium (HWE)(P= 0.001) in present study. Stratified analysesby smoking revealed that miRNA-423 rs6505162 variants significantly decreased the LC risk in heterozygous (CA vs. CC, adjusted OR = 0.14, 95% CI = 0.03 ~ 0.81, P= 0.028), recessive(AA vs. CA + CC, adjusted OR = 0.17, 95% CI = 0.03 ~ 0.90, P= 0.038)genetic models in smoking population. However, miRNA-196A2rs11614913, miRNA-196A2rs12304647, miRNA-146Ars2910164, miRNA-16-1rs1022960, miRNA-608rs4919510, andmiRNA-27a rs895819polymorphisms were not significantly associated withLC. The findings of our study indicate a potential decrease inLC risk among smokers with the miRNA-423 rs6505162variants, while an increase in risk is associated with miRNA-6811 rs2292879 polymorphismsin the population of SouthernChinese. However, further well-designed researchis necessary to fully understand the precise impact of these twoSNPs on the development of LC.