Abstract
Acting as a really common cancer in the world, bladder cancer has taken many people's life away. MiRNAs and mRNA have been reported can regulate the expression of cancers. In this study, the role of RAB2A and miR-381-3p was fully studied in bladder cancer. qRT-PCR assay probe the expression of RAB2A and miR-381-3p in bladder cancer cells. Meanwhile, colony formation assay, EdU assay, flow cytometry analysis, JC-1 assay and western blot assay were implemented to detect the progression of bladder cancer cells. Silenced RAB2A could reduce the cell proliferation of bladder cancer, and activate the apoptosis. Meanwhile, miR-381-3p could bind to RAB2A in bladder cancer cells and overexpressed miR-381-3p could inhibit the progression of bladder cancer cells. MiR-381-3p/RAB2A axis activates cell proliferation and inhibits cell apoptosis in bladder cancer.
Highlights
Bladder cancer is a type of epithelial cell carcinoma
MRNA RAB2A expression was detected in bladder cancer cells (T24, 5637, J82 and RT-4) and normal human bladder epithelial cells (SV-HUC-1) by qRT-PCR assay (Figure 1A)
RAB2A can enhance the invasiveness of breast cancer by regulating MT1-MMP and E-cadherin [20]
Summary
Bladder cancer is a type of epithelial cell carcinoma. It is the second most common cancer of the urogenital tract. The incidence of bladder cancer is higher in men. This cancer is more common in whites than in blacks [1]. Bladder cancer begins when the cells lining the inner surface of the bladder change and their growth gets out of control, forming a mass called a tumor. Bladder tumors can be benign or malignant. Malignancy means that cancer cells can grow and spread to other parts of the body, a process called metastasis. A benign tumor does not metastasize to other parts of the body. Benign bladder tumors are rare [2]
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