Abstract
Objective To investigate the association between the genetic variant in the promoter region of miR-34b/c and cancer risk. Methods Databases such as PubMed、EMBase、Wanfang、VIP、CNKI and so on were searched comprehensively. Based on the including and excluding criteria, literatures that were eligible were screened and data were retrieved. Meta analysis was performed by RevMan 5.1 software. Results Through searching and manually searching relevant references, a total of 9 articles with 10 independent studies were included. No significant associations were detected in C vs T, CC vs TT, CC+ CT vs TT and CC vs CT+ TT comparison models. However, in the CT vs TT comparison model, the result showed a significant association (Z=2.33, P=0.02). Meanwhile, subgroup analysis of hepatocellular carcinoma and colorectal cancer both showed significant associations with the polymorphism, with C vs T (OR=1.11, Z=2.10, P=0.04), CT vs TT (Z=2.40, P=0.02), CC+ CT vs TT (Z=2.45, P=0.01) and CC vs TT (OR=0.66, Z=2.43, P=0.02), CC vs CT+ TT (OR=0.67, Z=2.40, P=0.02) respectively. The C allele increased significantly the susceptibility of hepatocellular carcinoma, and the CC genotype reduced significantly the susceptibility of colorectal cancer. Conclusion The genetic variant in the promoter region of miR-34b/c rs4938723 T>C is significantly associated with the susceptibility of hepatocellular carcinoma and colorectal cancer. Key words: Neoplasms; Polymorphism, genetic; Meta-analysis; miR-34b/c
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