Abstract
miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia
Highlights
Bronchopulmonary dysplasia (BPD) has been getting more attention as neonatologists from across the world are getting better in saving the lives of premature neonates
We have recently reported (Nat Comm 8:1173) that hyperoxia exposure in our in vitro and in vivo modeling systems of hyperoxia-induced lung injury (HALI) and BPD leads to an upregulation of the microRNA 34a
Utilizing genetic loss- and gain- of function strategies, we show that miR34a inhibition ameliorates the pulmonary phenotype of BPD, at least in part, via one of the downstream targets of miR34a, namely Angiopoietin1/Tie 2 signaling
Summary
BPD has been getting more attention as neonatologists from across the world are getting better in saving the lives of premature neonates.
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