Abstract
BackgroundMany studies have reported several transcriptionally deregulated microRNAs (miRNAs) in papillary thyroid cancer (PTC) tissue in comparison with benign thyroid nodules and normal thyroid tissues. However, the correlation between miRNA expressions and PTC recurrence still remains unclear.MethodsThe PTC patients who scheduled to undergo total thyroidectomy by the same surgical team in Ningbo NO.2 Hospital from March 1998 to March 2008 were enrolled in this study. The clinical and pathological characteristics of each patient were recorded in detail. The selected miRNA expressions were detected using quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Potential predictive factors for cancer recurrence were evaluated by univariate and multivariate Cox proportional hazard analysis.ResultsA total of 78 patients were enrolled with 49 females at a mean age of 45.8 years. Enrolled patients were divided into two groups: nonrecurrent group (n = 54) and recurrent group (n = 24). The results from the univariate Cox proportional hazard analysis revealed that primary tumor size, TNM stage, extrathyroid extension, miR-221, and miR-222 expressions were significantly associated with PTC recurrence (P < 0.05). The tissue expression of miR-221 was the only independent risk factor for PTC recurrence (HR 1.41; 95%CI 1.14–1.95, P = 0.007) by multiple Cox proportional hazard analysis.ConclusionsThis study identified the potential role of miR-221 as a prognostic biomarker for the recurrence in PTC.
Highlights
Many studies have reported several transcriptionally deregulated microRNAs in papillary thyroid cancer (PTC) tissue in comparison with benign thyroid nodules and normal thyroid tissues
Patient characteristics and PTC recurrence A total of 78 eligible patients with a mean age of 45.8 years and mean tumor size of 24.5 mm were enrolled in this study with signed informed consent
It has been observed that those patients with higher American Thyroid Association (ATA) risks, higher MSKCC–NY risks, a larger primary tumor size, or higher TNM stages were more likely to result in the PTC recurrence (P < 0.05)
Summary
Many studies have reported several transcriptionally deregulated microRNAs (miRNAs) in papillary thyroid cancer (PTC) tissue in comparison with benign thyroid nodules and normal thyroid tissues. The correlation between miRNA expressions and PTC recurrence still remains unclear. The most common histological type of all thyroid cancers is papillary thyroid cancer (PTC), which is defined as a differentiated neoplasia and accounts for approximately 80%. Most PTC patients are with good prognosis, and the 10-year survival rate is about 90% [2]. The incidence of lymph node metastasis can be as high as 20–50% [3], and PTC patients undergoing total thyroidectomy are with a regional recurrence of 5–20% [4, 5]. Needle aspiration biopsy is the gold standard for diagnosis, but the predicative value for recurrence is rather limited [6].
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