Abstract
Severe community-acquired pneumonia (SCAP) is a common critical disease in the intensive care unit (ICU). This study aims to evaluate the clinical significance of miR-181b in SCAP, which has been revealed to be dysregulated in acute respiratory distress syndrome events due to SCAP. There were 50 SCAP patients and 26 healthy volunteers were recruited in this study. The expression of miR-181b was detected by RT-qPCR and the difference between SCAP and healthy controls was evaluated. The diagnosis and prognosis value of miR-181b was assessed by the receiver operating characteristics (ROC), Kaplan-Meier, and Cox regression analysis. miR-181b was significantly downregulated in SCAP compared with healthy controls. The downregulation of miR-181b showed a significant association with the white blood cell count, absolute neutrophils, and the C-reactive protein of patients. The downregulation of miR-181b could distinguish SCAP patients from healthy controls and predicate the poor prognosis of SCAP patients. Downregulated miR-181b serves as a diagnosis and prognosis biomarker for SCAP, which may be useful biological information for the early detection and risk estimation of SCAP.
Highlights
Pneumonia is one of the lower respiratory tract infections, which accounts for the high mortality of patients (Robert et al, 2018)
The serum expression level of miR-181b was significantly lower in Severe community-acquired pneumonia (SCAP) patients compared with healthy controls (P < 0.001, Figure 1)
According to the average expression level of miR-181b in SCAP patients, the SCAP patients were divided into the high miR-181b group (n = 21) and the low miR-181b group (n = 29)
Summary
Pneumonia is one of the lower respiratory tract infections, which accounts for the high mortality of patients (Robert et al, 2018). Severe community-acquired pneumonia (SCAP) is the most frequent and severe type of pneumonia, requiring hospitalization and intensive care unit (ICU) treatment with the high mortality rates of 30-50% in ICU (Jain et al, 2015a; Torres et al, 2019). Despite the occurrence of SCAP has been decreased in the past decades, SCAP remains a challenge in the clinic (Murdoch, 2016). The proportion of primary viral pneumonia among all causes of SCAP is underestimated, which is comparable to the proportion of bacterial pneumonia (Jain et al, 2015b). Due to the limitations in the detection of specific pathogen responsible for SCAP and the lack of clinical guidelines, the early detection and the prognosis of SCAP patients were still unsatisfactory (Murdoch et al, 2009). Identification of potential biomarkers could improve the clinical care of patients and provide novel therapeutic strategies
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