MIR17HG polymorphisms contribute to high-altitude pulmonary edema susceptibility in the Chinese population

Lining Si,Qifu Long,Yahui Jiang,Yanli Zhao,Haiyang Wang,Yun Yi,Rong Wang

doi:10.1038/s41598-022-06944-8

Abstract

High-altitude pulmonary edema (HAPE) is a common acute altitude sickness. This study was designed to investigate the effect of MIR17HG polymorphisms on HAPE risk in the Chinese population. The Agena MassARRAY platform was used to genotype six single-nucleotide polymorphisms (SNPs) in the MIR17HG gene in 244 HAPE patients and 243 non-HAPE controls. The odds ratio (OR) and 95% confidence interval were used to evaluate the association between each MIR17HG polymorphisms and the risk of HAPE under a polygenetic model. Statistical analysis was performed using the χ2 test. Multifactor dimensionality reduction (MDR) analysis was used to analyze the impacts of SNP–SNP interactions on the risk of HAPE. According to the allele model, the HAPE risk of people with the rs7318578 A allele of MIR17HG was lower than that of people with the C allele (OR 0.74, p = 0.036).Logistic regression analysis of four models for all selected MIR17HG SNPs showed significant differences in the frequencies of rs7318578 (OR 0.74, p = 0.037) and rs17735387 (OR 1.51, p = 0.036) between cases and controls. The results of the sex stratification analysis showed that among males, rs17735387 in the MIR17HG gene is associated with an increased risk of HAPE. MDR analysis showed that the best combination model was a three-locus model incorporating rs72640334, rs7318578, and rs7336610. This study revealed the correlations between rs7318578 and rs17735387 on the MIR17HG gene and the risk of HAPE in the Chinese population, providing a theoretical basis for the early screening, prevention, and diagnosis of HAPE in high-risk populations.

Highlights

High-altitude pulmonary edema (HAPE) is a common acute altitude sickness
This study explored the impact of the MIR17HG polymorphisms on the risk of HAPE in the Chinese population
Multiple reports have revealed that MIR17HG polymorphisms are associated with various disease risks[23,24], there is no report about the polymorphisms of MIR17HG and the risk of HAPE

Summary

Introduction

High-altitude pulmonary edema (HAPE) is a common acute altitude sickness. This study was designed to investigate the effect of MIR17HG polymorphisms on HAPE risk in the Chinese population. The results of the sex stratification analysis showed that among males, rs17735387 in the MIR17HG gene is associated with an increased risk of HAPE. Abbreviations HAPE High-altitude pulmonary edema AMS Acute mountain sickness SNP Single nucleotide polymorphism HWE Hardy–Weinberg equilibrium OR Odds ratio 95% CI 95% confidence intervals CT Computed tomography MAF Minor allele frequency MM Multiple myeloma MIR17HG MiR-17-92 cluster host gene LD Linkage disequilibrium. When people are rapidly exposed to high-altitude environments, low oxygen air tension can cause acute pulmonary artery vasoconstriction, which in turn leads to an increase in high pulmonary artery pressure. It is generally believed that the key to its occurrence is the pulmonary vasoconstriction and increased pulmonary arterial pressure caused by hypoxia at high altitude. We believe that lncRNA polymorphisms may be associated with genetic susceptibility to high altitude pulmonary edema

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