Abstract
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide. It accounts for approximately 30~40% of glomerular diseases in China. However, the exact pathogenesis of IgAN is not well established. This study aimed to explore the association between MIR17HG polymorphisms and IgAN susceptibility. Six single nucleotide polymorphisms (SNPs) of MIR17HG were genotyped in 417 patients with IgAN and 424 healthy controls. The association analysis was conducted by logistic regression adjusted for age and gender in multiple genetic models and different subgroups. Our results revealed that rs72640334 and rs1428 increased the susceptibility to IgAN in total populations (p<0.05). The stratification analysis by age indicated that rs72640334 enhanced the risk of IgAN people older than 35years, while rs7318578 played a protective role in the development of IgAN patients aged >35years (p<0.05). In addition, MIR17HG-rs72640334 could facilitate the occurrence of IgAN in females (p<0.05). In Lee's grade III-Vsubgroup, rs72640334 and rs7336610 have an increasing effect on IgAN risk, while rs7318578 has a decreasing effect on IgAN susceptibility (p<0.05). Our findings suggested that MIR17HG genetic polymorphisms were correlated with IgAN susceptibility. It provided new evidence for the potential molecular mechanism of IgAN and may serve as a new biomarker for the treatment and early diagnosis of IgAN.
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