MiR-381-3p Involves in Glioma Progression by Suppressing Tumor-Promoter Factor ANTXR1.

Zhiqiang Dong,Zhenshan Gao,Qiang Yang,Liang Niu,Jinglong Zhang,Guokuo Hou

doi:10.1155/2021/4883509

Abstract

Accumulating studies revealed association between development of glioma and miRNA dysregulation. A case in point is miR-381-3p, but its mechanism in glioma is unclear yet. In this work, we confirmed that overexpressed miR-381-3p repressed biological functions of glioma cells. Additionally, we also discovered that upregulated anthrax toxin receptor 1 (ANTXR1) was negatively mediated by miR-381-3p. We further proved that miR-381-3p-targeted ANTXR1 was able to counteract the suppression of miR-381-3p on biological functions of glioma. We concluded that miR-381-3p and ANTXR1 were both important factors in modulating glioma progression. miR-381-3p/ANTXR1 axis is expected to be a molecular target for glioma.

Highlights

Glioma is the most frequent primary central nerve tumor, which originates from glial progenitor cells [1]
Dulbecco’s Modified Eagle’s Medium (DMEM; Life Technologies, Carlsbad, CA)+10% fetal bovine serum (FBS; Life Technologies)+100 U/mL penicillin+100 μg/mL streptomycin was applied for cell culture
It constrains the malignant behaviors of papillary thyroid carcinoma, OSCC, and cervical cancer [9, 10, 12], but its regulatory role in glioma has never been reported before

Summary

Introduction

Glioma is the most frequent primary central nerve tumor, which originates from glial progenitor cells [1]. The 10-year survival rate of low-grade glioma is about 47%, while the average survival time of patients with grade 4 glioma such as glioblastoma is only 15 months [2, 3]. The last few years have witnessed remarkable discovery of glioma biology due to constant focus, such as pivotal molecular and genetic mechanisms. Molecular features of these tumors have expanded our vision of tumorigenesis and progression and provided abundant targeted pathways [5]. There is no research showing that miR-381-3p can modulate glioma progression

Methods

Results

Conclusion