Abstract
BackgroundDue to the lack of suitable biomarker to early diagnosis of gastric cancer patients for effective treatment, nowadays there are many experiment acts to use novel biomarker such as miRNAs to early diagnosis of GC. MethodsPeripheral blood specimens were collected before treatment from 113 patients with gastric cancer. The CEACAM5 and miR-335 expression were evaluated by quantitative RT-PCR. ResultCEACAM5 mRNA expression was significantly lower in patients with AGC than patients with EGC (P < .05) and miR-335 was significantly up-regulated in AGC compare to EGC (P < .05). Moreover, CEACAM5 and miR-335 expression level correlated significantly with LNM, distant metastasis, and TNM stage (P > .05). ConclusionOur findings demonstrate a possible relationship between the deregulation of miR-335 and CEACAM5 with GC progression, also miR-335 and CEACAM5 have the potential to recognize the AGC than EGC.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
