Abstract
miR-301, Pleiotropic MicroRNA in Regulation of Inflammatory Bowel Disease and Colitis-Associated Cancer.
Highlights
Reviewed by: Girdhari Lal, National Centre for Cell Science, India Grazia Serino, University of Bari Medical School, Italy
Recent data demonstrate that Inflammatory bowel disease (IBD) arises from the complex interplay of genetic and environmental factor caused by a change in the intestinal microbiota [1]
Single layered intestinal epithelial cells (IECs) establish a semipermeable intestinal barrier (IB) which allows the dual role of transporting nutrients and avoiding the passage of pathogens
Summary
Reviewed by: Girdhari Lal, National Centre for Cell Science, India Grazia Serino, University of Bari Medical School, Italy. Studies using human adipose-derived stem cells show the important role of miRNA-301a in the suppression of apoptosis signal-regulating kinase 1 expression. MiR-301a inhibits SMAD4 expression to regulate invasion, migration in vitro as well as tumor growth in vivo in pancreatic cancer [15].
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