Abstract
microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through post-transcriptional interactions with mRNA. miRNAs have recently emerged as key regulators of various cancers. Although miR- 27a has been implicated in several other cancers, its role in hepatitis B virus-related hepatocellular carcinoma (HCC) is unknown. In this study, we showed miR-27a to be frequently up-regulated in HCC tissues and HCC cell lines (HepG2 and Huh7). Overexpression of miR-27a enhanced cell proliferation, promoted migration and invasion, and activated cell cycling in HepG2 and Huh7 cells. In summary, our results suggest that up-regulation of miR-27a may play an oncogenic role in the development of HCC and might thus be a new therapeutic target in HCC patients.
Highlights
Hepatocellular carcinoma (HCC) is one of the most common cancers and represents the third-leading cause of cancer-related death worldwide (El-Serag et al, 2008; Jemal et al, 2011)
We further investigated whether miR-27a contributed the expressions of miR-27a in HCC tumors and adjacent to cell migration and invasion properties
We found in HepG2 and Huh7 cells by 77% and 150% (p
Summary
Hepatocellular carcinoma (HCC) is one of the most common cancers and represents the third-leading cause of cancer-related death worldwide (El-Serag et al, 2008; Jemal et al, 2011). The vast majority of cases of HCC occur in the setting of liver cirrhosis caused by chronic infection with hepatitis B (HBV) and C (HCV) viruses and alcoholic liver disease (Tinkle et al, 2012). The sensitivity and specificity of a-Fetoprotein (AFP) for diagnosis of HCC are not satisfying (Zinkin et al, 2008). Biomarkers for early detection and follow-up of HCC are absent, accounting for late diagnosis and subsequent poor prognosis. It is necessary to improve our understanding of the molecular pathogenesis of HCC and develop new target therapies and diagnostic biomarkers
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