Abstract
BackgroundRecently, microRNA-20a (miR-20a) has been reported to influence the clinical features and may have prognostic value in human cancers. The present meta-analysis assessed the prognostic role of miR-20a in various carcinomas.MethodsLiterature searches of seven electronic databases were performed for eligible articles of the prognostic role of miR-20a in human cancers. Hazard ratios (HR) for overall survival (OS), disease free survival (DFS), progression-free survival (PFS) as well as their 95% confidence intervals (95%CIs) were used to assess the influence of miR-20a expression on patient prognosis. Odds ratio (OR) and 95%CIs were applied to evaluate the correlation between miR-20a expression and clinicopathological characteristics.ResultsBased on the OS analyzed by log rank tests, there was a significant association between miR-20a levels and OS by fixed effects model. By subgroup analyses, the significance was also observed in the studies of specimen derived from blood and gastrointestinal cancer group. The independent prognostic role of miR-20a expression for the OS was observed significantly by fixed effects model. In addition, we observed significant association between miR-20a expression levels and DFS of log rank tests, DFS of cox regression. Significant relation of gender/differentiation and the expression level of miR-20a was identified.ConclusionsBase on the findings, the elevated miR-20a expression level is related to poor prognosis of gastrointestinal cancer patients. As for other types of carcinomas, the results are still not stable and more studies are required to further identify miR-20a prognostic values. In addition, miR-20a expression level is relatively higher in women than that in men, and increased miR-20a expression level is linked to poor tumor differentiation.
Highlights
MicroRNA-20a has been reported to influence the clinical features and may have prognostic value in human cancers
Eligibility criteria Studies from the initial researches that satisfy the criteria below were thought to be eligible. (1) studies evaluated the prognostic value of blood or tissue miR-20a level in various human cancers. (2) the relationships between miR-20a expression and patients’ survival were described; (3) Studies have sufficient data to calculate the hazard ratios (HR) and 95%confidence interval (95%CI) for survival rates or odds ratio (OR) and 95% confidence intervals (95%CIs) for the correlation between miR-20a expression and clinicopathological characteristics. (4) there was no restrictions on the methods of detecting the miR-20a expression levels in the cancer patients by some specific methods, such as qRT-relapse free survival (RFS) Recurrence-free survival (PCR), microarray or etc
We identified that the elevated miR-20a expression was linked to poor prognosis of cancer patients
Summary
MicroRNA-20a (miR-20a) has been reported to influence the clinical features and may have prognostic value in human cancers. The present meta-analysis assessed the prognostic role of miR-20a in various carcinomas. One of the reasons is lack of effective biological markers help to define subgroups of patients who might benefit or MicroRNAs (miRNA) are small noncoding molecules of with a length of approximately 18–24 nucleotides, and can negatively regulate their target genes expression [1, 2]. Many miRNAs have been identified to express abnormally in human malignancies and can play an oncogenic or anti- oncogenic role in tumor biological behaviors [3, 4]. Owing to its stability and detectability in tissues/blood, miRNA is one of the most promising biomarkers for the prognosis of human cancers [5,6,7].
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