Abstract
Laryngeal carcinoma (LC) is one of the common human cancer types. MicroRNAs (miRNAs) were reported to be the essential regulators in cancer diagnosis, treatment, and prognosis. It was reported that miR-206 expression was reduced in various neoplastic diseases. However, the role and functional mechanism of miR-206 in LC progression remain unclear. In this research, miR-206 was found to be associated with tumor-node-metastasis (TNM) staging. In addition, the area under the curve (AUC) of miR-206 was 0.902 for diagnosis of LC and 0.854 for differential diagnosis of stage I-II and stage III-IV patients. Low expression of miR-206 was associated with poor prognosis of LC patients. miR-206 expression was an independent factor affecting the prognosis of LC patients, as revealed by the Cox regression analysis. In vitro experiments demonstrated that miR-206 overexpression reduced cell multiplication, invasion, and migration and increased cell apoptosis in LC cells. Moreover, SOX9 was a target of miR-206, and miR-206 negatively regulated SOX9 expression. Collectively, miR-206 might be a promising biomarker with diagnostic and prognostic value for LC, and the miR-206/SOX9 axis might be a candidate target for LC therapy.
Highlights
Laryngeal carcinoma (LC) is a malignancy with the highest incidence among head and neck cancers and accounts for 1%–5% of human cancer types [1]
Previous literature studies reported that miRNAs functioned as activators or inhibitors in tumor multiplication and metastasis [22]. miR-206 was confirmed to play the inhibition role in some tumors [23]. miR-206 was proved to be downregulated in colorectal cancer and targeted Bcl-2 to mediate chemical resistance, multiplication, and apoptosis of colorectal cancer cells [24]
We found that miR-206 was reduced in LC tissues, cells, and serum, indicating that miR-206 played a vital role in LC
Summary
Laryngeal carcinoma (LC) is a malignancy with the highest incidence among head and neck cancers and accounts for 1%–5% of human cancer types [1]. Tumor invasion and metastasis were the main causes for the poor survival rate of LC patients [4]. MiR-206 overexpression depressed cell proliferation in Hep-2 cells by targeting cyclin D2, and upregulation of miR-206 could inhibit tumor growth in the mice model of laryngeal squamous cell carcinoma [18]. E data showed that miR-206 level was correlated with tumor-node-metastasis (TNM) staging, suggesting that miR-206 might be a potential diagnostic indicator for LC. We observed that LC patients with a low level of miR-206 exhibited a worse survival rate. Overall, these findings displayed that miR-206 played a suppressive role in LC development, providing a possible diagnosis and prognosis biomarker for LC
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