MiR-149 and miR-499 gene polymorphism and the incident of ischemic stroke in the Asian population: From a case-control study to meta-analysis

Abstract

ObjectivesMiRNAs are the most abundant class of regulatory non-coding RNA, which may exert a significant role in the pathogenesis of ischemic stroke(IS). Previous studies have focused on the relationship between miRNA polymorphism and IS risk, but the results remain inconsistent. Therefore, we first conducted a case-control study to explore the association, and subsequently performed a meta-analysis to further to clarify the association of miRNA polymorphism with risk of ischemic stroke. Patients and methodsWe first conducted a case-control study including 567 IS patients and 552 controls. Then we performed a meta-analysis combining the current study and previous studies with a total of 3015 cases and 2874 controls on miR-149 rs2292832 and 4119 cases and 4085 controls on miR-499 rs3746444 to further confirm our findings by searching PubMed, Web of Science and Chinese National Knowledge Infrastructure (CNKI) databases database up to Nov 2019. ResultsIn our case-control study, no association between miR-499 rs3746444, miR-149 rs2292832 and IS were found. When combined with previous studies, however, a significant relationship between miR-149 rs2292832 and ischemic stroke incident was found under recessive model and allelic model. In other words, CC genotype and C allele of miR-149 rs2292832 were increased risk of ischemic stroke. ConclusionOur meta-analysis results suggest that miR-149 rs2292832 might contribute to stroke susceptibility in the Asian populations.