Abstract
Background Many researchers have confirmed that miRNAs are involved in the pathogenesis of gastric cancer (GC). This study focused on investigating the specific functions of miR-139-5p in GC. Methods MiR-139-5p and TPD52 expressions were observed by qRT-PCR or western blot in GC. The functional mechanism of miR-139-5p was explored by the luciferase reporter assay, transwell assay, and MTT assay. Results MiR-139-5p downregulation and TPD52 upregulation were detected in GC. Adverse clinical features and prognosis in GC patients were related to low miR-139-5p expression. MiR-139-5p overexpression restrained GC cell proliferation and metastasis. Furthermore, miR-139-5p directly targeted TPD52. TPD52 silencing blocked GC progression. And TPD52 upregulation weakened the antitumor effect of miR-139-5p in GC. Conclusion MiR-139-5p inhibits GC cell proliferation and metastasis through downregulating TPD52.
Highlights
Gastric cancer (GC) ranks third in human malignancies [1]
Patients with early gastric cancer (GC) have a better prognosis after treatment. e postoperative effect is better for patients over 60 years old, while patients under 30 years old tend to have poor prognosis [5]. erefore, it is necessary to strengthen the attention to the symptoms of early GC and the monitoring of high-risk groups in order to increase the detection rate of patients with early GC
MiR-139-5p Downregulation and tumor protein D52 (TPD52) Upregulation Were Detected in GC
Summary
Many researchers have confirmed that miRNAs are involved in the pathogenesis of gastric cancer (GC). is study focused on investigating the specific functions of miR-139-5p in GC. Many researchers have confirmed that miRNAs are involved in the pathogenesis of gastric cancer (GC). Is study focused on investigating the specific functions of miR-139-5p in GC. MiR-139-5p and TPD52 expressions were observed by qRT-PCR or western blot in GC. E functional mechanism of miR-139-5p was explored by the luciferase reporter assay, transwell assay, and MTT assay. MiR-139-5p downregulation and TPD52 upregulation were detected in GC. Adverse clinical features and prognosis in GC patients were related to low miR-139-5p expression. MiR-139-5p overexpression restrained GC cell proliferation and metastasis. TPD52 upregulation weakened the antitumor effect of miR-139-5p in GC. MiR-139-5p inhibits GC cell proliferation and metastasis through downregulating TPD52
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