Abstract
The microRNA, miR-139-5p, has been proved to play important roles in regulating tumor progression, including prostate cancer, osteosarcoma, esophageal cancer, and so on, but its correlation of hepatocellular carcinoma (HCC) still remains unclear. Here we found that hsa-miR-139-5p (miR-139-5p) was decreased in HCC samples compared with normal liver tissues, and a lower expression of miR-139-5p was connected to a poorer prognosis. Mechanism study indicated that a decreased/increased miR-139-5p could increase/decrease HCC cells invasion and proliferation capacities via increasing SLITRK4 expression, what’s more, the reverse assays also confirmed the conclusion when we knocked down SLITRK4 in the miR-139-5p low-expression cells. Luciferase assay confirmed that miR-139-5p could directly bind to the 3′UTR of SLITRK4 mRNA to regulate its expression. Together, these findings show the importance of miR-139-5p/SLITRK4 pathway in HCC growth and progression and may provide new targets for us to better arrange the progression of HCC.
Highlights
Hepatocelluar carcinoma (HCC) is one of the main health problems faced by the public across the word
Our study showed that the miR-139-5p expression was decreased in HCC tumor samples, which could increase HCC invasion and proliferation capacity by increasing SLIT and NTRK like family member 4 (SLITRK4) expression
The result showed that the expression of miR-139-5p was lower in HCC samples than that in normal tissues (Figure 1B), what’s more, the heat-map in YM500v2 database confirmed the result (Figure 1C)
Summary
Hepatocelluar carcinoma (HCC) is one of the main health problems faced by the public across the word. HCC will take a large amount of burden in the public health expenditure, it is very essential for us to deeply study the biomarkers related to the progression of HCC and provide novel therapies for better treatments of HCC. MiRNAs can silence the target genes by post-transcriptional regulation by binding to the 3 untranslated region (UTR) of target genes [6], and dysregulation of the miRNAs has been proved to have significant correlation with tumor initiation, progression and metastasis [7,8,9,10]. The dysregultion of miR-139-5p in HCC may lead crucial outcomes in the progression of HCC
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