Abstract
An automated high-throughput flow injection analysis electrospray mass spectroscopy system was developed in-house for the purity estimation of tens of thousands of multiple parallel synthesis samples from the Novartis Pharma Combinatorial Chemistry programme. A Visual Basic application called Rack Viewer enables the sample submitting chemists to inspect their spectroscopic results in a fast, direct and easy way. Within RackViewer, a novel 3-D display of an entire 96-well rack's mass spectral ion current highlights systematic patterns in the combinatorial chemistry synthesis. In addition the system was adapted to allow the seamless incorporation of 96-well racks containing liquid chromatography fractions into the high-throughput analysis queues.
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