Abstract
Powder mixtures of paracetamol and a spray-dried lactose, Pharmatose® DCL 11, after adding glidant and lubricant, were continuously tabletted on an eccentric tabletting machine into convex-faced tablets with diameters ranging from 1.5 to 5 mm, to graded maximum relative densities and a ratio of overall thickness at minimum distance of the punch faces to, diameter of one, resulting in tablets with identical geometrical proportions. Force at upper and lower punches and the distance between the upper and lower punch holders were measured during tabletting, and the resulting tablets were tested for mechanical strength and tendency to cap. The results indicate that the mechanical stability of minitablets containing paracetamol is equal to, and at high pressures higher than that of normal-sized tablets. The capping tendency of minitablets is reduced. This leads to the conclusion that higher contents of paracetamol could be tabletted, if minitablets were produced.
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