Abstract
Biofouling causes huge economic loss and generates serious ecological issues worldwide. Marine coatings incorporated with antifouling (AF) compounds are the most common practices to prevent biofouling. With a ban of organotins and an increase in the restrictions regarding the use of other AF alternatives, exploring effective and environmentally friendly AF compounds has become an urgent demand for marine coating industries. Marine microorganisms, which have the largest biodiversity, represent a rich and important source of bioactive compounds and have many medical and industrial applications. This review summarizes 89 natural products from marine microorganisms and 13 of their synthetic analogs with AF EC50 values ≤ 25 μg/mL from 1995 (the first report about marine microorganism-derived AF compounds) to April 2017. Some compounds with the EC50 values < 5 μg/mL and LC50/EC50 ratios > 50 are highlighted as potential AF compounds, and the preliminary analysis of structure-relationship (SAR) of these compounds is also discussed briefly. In the last part, current challenges and future research perspectives are proposed based on opinions from many previous reviews. To provide clear guidance for the readers, the AF compounds from microorganisms and their synthetic analogs in this review are categorized into ten types, including fatty acids, lactones, terpenes, steroids, benzenoids, phenyl ethers, polyketides, alkaloids, nucleosides and peptides. In addition to the major AF compounds which targets macro-foulers, this review also includes compounds with antibiofilm activity since micro-foulers also contribute significantly to the biofouling communities.
Highlights
Biofouling is defined as the undesirable colonization of submerged man-made surfaces by fouling organisms, including micro-organisms such as bacteria, algae and protozoa, and macro-organisms such as barnacles, bryozoans and tubeworms [1,2]
There is an urgent demand for search of novel AF compounds without causing environmental issues
Potentials and challenges are discussed with respect to the development of environmentally benign AF paints using natural products isolated from marine microorganisms
Summary
Biofouling is defined as the undesirable colonization of submerged man-made surfaces by fouling organisms, including micro-organisms such as bacteria, algae and protozoa, and macro-organisms such as barnacles, bryozoans and tubeworms [1,2] These fouling organisms cause huge material and economic loss in marine operations [3,4,5], and create a series of environmental problems such. Coating the substrata with antifouling (AF) paints containing antifoulants or AF compounds is the most commonly used strategy to prevent marine biofouling Due to their toxicities toward non-target organisms, some AF compounds have raised many environmental issues and led to increasing regulation of their usage [8,9,10]. Potentials and challenges are discussed with respect to the development of environmentally benign AF paints using natural products isolated from marine microorganisms
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