Mining the pre-diagnostic antibody repertoire of TgMMTV-neu mice to identify autoantibodies useful for the early detection of human breast cancer

Sasha E Stanton,Jianning Mao,Lauren Rastedder,Mary L Disis,John Ladd,Ekram Gad,Samir Hanash

doi:10.1186/2051-1426-1-s1-p59

Abstract

Meeting abstracts Breast cancer has been shown to be immunogenic and can stimulate an antibody immune response. Because of this immunogenicity, identification of early breast tumor antigens could allow identification of autoantibodies for the early detection of breast cancer. In this study, the

Highlights

Breast cancer has been shown to be immunogenic and can stimulate an antibody immune response
The mammary tumors that develop in these mice are genotypically similar to human luminal breast cancer and the mammary tumor development in these mice can be evaluated longitudinally, allowing for collection of sera prior to tumor development and identification of tumor specific antibodies representing the earliest alterations in the malignant transformation of normal mammary epithelium
We identified 6 antigens that were present in mice prior to the development of mammary tumors (Pdhx, Otud6b, Stk39, Zpf238, Lgals8, and Vps35)

Summary

Introduction

Breast cancer has been shown to be immunogenic and can stimulate an antibody immune response. Mining the pre-diagnostic antibody repertoire of TgMMTV-neu mice to identify autoantibodies useful for the early detection of human breast cancer Identification of early breast tumor antigens could allow identification of autoantibodies for the early detection of breast cancer.

Results

Conclusion