Abstract
The misuse of antimicrobials is causing an alarming increase in the appearance of antibiotic-resistant microorganisms. In this context, the identification of novel antibiotics against new targets and with low rates of resistance development is a major global challenge. In this article, we highlight a number of recent articles that exploit a variety of in vitro, in vivo and in silico state-of-the-art approaches to identify and develop new antimicrobials. Rapid progress in this research field will be crucial to combating a global health problem, antimicrobial resistance, that is expected to be the leading cause of death by 2050.
Highlights
The misuse of antimicrobials is causing an alarming increase in the appearance of antibiotic-resistant microorganisms
The emergence of AMR correlates with the misuse of antibiotics, and its rise is restricted to animal and human pathogens and affects economically relevant phytopathogens
A recent report published in Microbial Biotechnology used a novel bacteriophage recombinase system, Redab7029, to efficiently exchange the natural promoters of the seven cryptic polyketide synthase/non-ribosomal peptide synthetase BGCs present in the genome of the antimicrobial producer and plant-growth-promoting bacterium Paraburkholderia megapolitana DSM 23488 (Zheng et al, 2020)
Summary
Matilla2* 1Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
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