Minimum inhibitory but maximum non-hemolytic concentration of plasma-treated catheters coated with L. tridentata and O. vulgare extracts

Abstract

Antibacterial extract-coated catheters are promising alternatives to their conventional counterparts, but their hemocompatibility and thermal stability must be studied. Nosocomial bacteria have developed resistance to conventional antibiotics. Herein, the minimum inhibitory but non-hemolytic concentration (MIC-NH) and the thermal stability of Larrea tridentata (L. tridentata) and Origanum vulgare (O. vulgare) extract-coated catheters were studied. Besides, plasma pretreatment was performed to enhance the extract adhesion. Briefly, the extract-coated catheters prevent Staphylococcus aureus colonization without causing hemolysis by using L. tridentata and O. vulgare extracts at MIC-NH (5000 and 2500 μg ml−1, respectively). Moreover, it has been discovered that the extract coating and plasma treatment improved the thermal stability and the extract adhesion, respectively. Thus, this study provides evidence of alternative antibacterial but non-hemolytic extract-coated catheters.