Abstract
Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation. The methodologies for generating tolAPC vary greatly between different laboratories, making it difficult to compare data from different studies; thus constituting a major hurdle for the development of standardised tolAPC therapeutic products. Here we describe an initiative by members of the tolAPC field to generate a minimum information model for tolAPC (MITAP), providing a reporting framework that will make differences and similarities between tolAPC products transparent. In this way, MITAP constitutes a first but important step towards the production of standardised and reproducible tolAPC for clinical application.
Highlights
Immunotherapy with whole living cells shows great promise for the treatment of a wide variety of complex diseases
We reviewed a number of papers about tolerogenic antigen-presenting cells (tolAPC), and for each, we determined whether the data required by the MITAP document was present or not
Previous research has shown that uniform resource identifiers (URIs; i.e., URLs or Web addresses) given in papers have short half-lives (around a 25% loss three years after publication (Wren, 2008)), and either move or become inaccessible, in many cases before the papers have been published
Summary
Immunotherapy with whole living cells shows great promise for the treatment of a wide variety of complex diseases. A recent innovation in this field is the use of myeloid antigen-presenting cells (APC) with immunoregulatory function to treat autoimmune diseases, or to prevent destructive immune reactions after organ—or haematopoietic stem cell-transplantation (Amodio & Gregori, 2012; Hutchinson, Riquelme & Geissler, 2012; Hilkens & Isaacs, 2013; Van Brussel et al, 2014; Creusot et al, 2014; Thomas, 2014; Morelli & Thomson, 2014; Ten Brinke et al, 2015). Examples of these immunoregulatory APC include tolerogenic dendritic cells (tolDC) and regulatory macrophages (Mreg). TolAPC therapy holds the promise of a potentially curative treatment with low toxicity
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