Abstract
BackgroundThe minimum clinical important differences (MCIDs) of resilience instruments in patients with cancer have not been comprehensively described.This study was designed to evaluate MCIDs of 10-item and 25-item resilience scales specific to cancer (RS-SC-10 and RS-SC-25).MethodsFrom June 2015 to December 2018, RS-SCs were longitudinally measured in 765 patients with different cancer diagnoses at baseline (T0) and 3 months later (T1). The EORTC QLQ-C30, Connor-Davidson Resilience Scale, Hospital Anxiety and Depression Scale, and Allostatic Load Index were measured concurrently as anchors. Anchor-based methods (linear regression, within-group), distribution-based methods(within-group), and receiver operating characteristic curves (ROCs, within-subject) were performed to evaluate the MCIDs.Results623 of 765 (84.1%) patients had paired RS-SCs scores. Moderate correlations were identified between the change in RS-SCs and change in anchors (r = 0.38–0.44, all p < 0.001). Linear regression estimated + 8.9 and − 6.7 as the MCIDs of RS-SC-25, and + 3.4 and − 2.5 for RS-SC-10. Distribution-based methods estimated + 9.9 and − 9.9 as the MCIDs of RS-SC-25, and + 4.0 and − 4.0 for RS-SC-10. ROC estimated + 5.5 and − 4.5 as the MCIDs of RS-SC-25, and + 2.0 and − 1.5 for RS-SC-10.ConclusionsThe most reliable MCID is around 5 points for RS-SC-25 and 2 points for RS-SC-10. RS-SCs are more responsive to the worsening status of resilience in patients with cancer and these estimates could be useful in future resilience-based intervention trials.
Highlights
Introduction25-item Resilience Scale Specific to Cancer (RS-SC-25) as an aid for nurses, physicians and social workers to assess the resilience levels of patients [6]; RS-SC-25 was validated based on classic theory test, item response theory, and resilience-related empirical research [7, 8]
In China, about 4.5 million people were diagnosed with cancer and 2.9 million people died from it in 2019 [1].The mortality of cancer has been lowered owing to advancesYe et al Health Qual Life Outcomes (2020) 18:38125-item Resilience Scale Specific to Cancer (RS-SC-25) as an aid for nurses, physicians and social workers to assess the resilience levels of patients [6]; RS-SC-25 was validated based on classic theory test, item response theory, and resilience-related empirical research [7, 8]
We postulated the following: (1) RS-SCs would be significantly associated with established scales, namely, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30, measuring quality of life), Connor-Davidson Resilience Scale (CD-RISC, measuring generic resilience), Hospital Anxiety and Depression Scale (HADS, measuring anxiety and depression), and Allostatic Load Index (ALI, measuring physiological load) in this study; and (2) changes in RS-SCs would be significantly associated with changes in established scales
Summary
25-item Resilience Scale Specific to Cancer (RS-SC-25) as an aid for nurses, physicians and social workers to assess the resilience levels of patients [6]; RS-SC-25 was validated based on classic theory test, item response theory, and resilience-related empirical research [7, 8]. To enable an appropriate assessment of resilience-related changes in patients with cancer, the minimum clinically important difference (MCID), which is the smallest change in score that patients perceive as beneficial or detrimental, is important to the clinical interpretation of scale data, especially for resilience-related interventions in different settings [10, 11]. To our knowledge, the MCID of resilience instruments in patients with cancer have not been comprehensively described. The minimum clinical important differences (MCIDs) of resilience instruments in patients with cancer have not been comprehensively described.This study was designed to evaluate MCIDs of 10-item and 25-item resilience scales specific to cancer (RS-SC-10 and RS-SC-25)
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