Abstract
The incidence of periprosthetic joint infection (PJI) is projected to increase as utilization of total knee replacements (TKR) grows. Two-stage removal and reimplantation operations are devastating for patients and place large economic burdens on hospitals. To prevent PJI, body mass index, nutrition, and diabetic control (hemoglobin A1c) should be considered preoperatively. Intraoperatively, expeditious surgery, minimizing tissue trauma, and betadine irrigation decrease PJI risk. The use of antimicrobial surgical dressings and avoidance of blood transfusions can reduce PJI postoperatively. Overall, to minimize PJI in TKRs, the entire surgical episode must be considered to examine the factors influencing the likelihood of PJI.
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