Abstract
Lumbar facet joint synovial cysts are fluid-filled sacs that develop near the facet joints in the lumbar spine. These cysts typically result from degenerative changes or wear and tear in the spine, leading to the enlargement of the facet joint capsule and the formation of a cyst which may cause symptomatic nerve root compression and may lead to radiculopathy, neurogenic claudication, and cauda equina syndrome. percutaneous aspiration of facet-joint synovial cysts are known to provide immediate improvement in symptoms and the absence of relapse during the follow-up period. These can be particularly beneficial for elderly and high-risk patients who are not suitable candidates for surgery or not willing to undergo surgery. These case report is submitted to highlights the effectiveness of this treatment option and suggests that it should be considered in the management of facet-joint synovial cysts.
Highlights
Head and neck cancer is the sixth most common cancer world-wide, resulting in approximately 550,000 diagnoses of new cases and 300,000 deaths per year globally
Positive Sphingosine kinase - 1 (SphK1) expression in oral leukoplakia is suggestive of an increased risk for malignant transformation which can be used as a biomarker tool
Higher SPHK1 expression in the oral squamous cell carcinoma (OSCC) may suggest an important role in the early stages of tumorigenesis
Summary
Head and neck cancer is the sixth most common cancer world-wide, resulting in approximately 550,000 diagnoses of new cases and 300,000 deaths per year globally. This study assesses the expression of sphingosine kinase - 1 (SphK1) in oral leukoplakia and oral squamous cell carcinoma (OSCC) and suggests its role as a potential biomarker tool for cancer risk assessment in oral leukoplakia. ORIGINAL ARTICLE plaques of questionable risk having excluded (other) known diseases or disorders that carry no increased risk for cancer and is the most common premalignant lesion found in mouth”.3. The gold standard method of assessing the malignant transformation risk of leukoplakia is the histopathological assessment of dysplasia.[5] it has been found that most of the oral cancer developed from lesions that lacked dysplastic changes.[6,7] there is a need to identify the molecular markers that can help in defining the risk potential of the precancerous lesions such as leukoplakia
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