Minimally invasive percutaneous nephrolithotomy in patients with autosomal dominant polycystic kidney disease and renal stone

Abstract

Objective To evaluate the safety and efficacy of minimally invasive percutaneous nephrolithotomy (MPCNL) in patients with autosomal dominant polycystic kidney disease (ADPKD) and renal stone. Methods The clinical data of patients with ADPKD and renal stone who underwent MPCNL in our hospital between January 2006 and December 2015 were analyzed retrospectively. Results twenty-seven renal units in 26 patients were included in our study. Twenty-five patients were performed in one stage MPCNL and one patient underwent second-stage MPCNL. The overall stone clearance rate was 88.9% (24/27). Three patients received ESWL because of residual calculi. The mean operation time was (68±34) min (range 20~140 min) and the mean blood loss was (57±49) ml (range 10~250 ml). The mean preoperative creatinine (Cr) and postoperative Cr level were (292±51) μmol/L and (219.8±33.6) μmol/L, (t=2.388, P=0.025). Two cases had fever postoperatively and four cases received blood transfusion because of hemorrhage. Conclusion MPCNL is a safe and effective approach for management of renal calculi in patients wih ADPKD. Key words: APPKD; Renal stone; Minimal invasion; PCNL