Abstract
Nutritional security is of vital importance for combating malnutrition and catering to increasing energy demands. Phytic acid is considered an anti-nutrient, which sequesters important metal ions, limiting their bioavailability. The lpa mutants of maize contain reduced phytate, thus increase its nutritive value. But low phytate is accompanied by negative pleiotropic effects. This article discusses the importance of lpa2 gene amongst available options, for precise DNA editing to simultaneously improve nutrition and avoid pleiotropic effects.
Highlights
Nutritional security is of vital importance for combating malnutrition and catering to increasing energy demands
Reduction in phytic acid content has been associated with negative pleiotropic effects like decreased germination percentage and weight of seeds
Impairment of the metabolic functions, otherwise carried out by inositol phosphates, in the phytic acid-related natural mutants could be a reason for their negative pleiotropic effects[6]
Summary
Nutritional security is of vital importance for combating malnutrition and catering to increasing energy demands. Reduction in phytic acid content has been associated with negative pleiotropic effects like decreased germination percentage and weight of seeds. Impairment of the metabolic functions, otherwise carried out by inositol phosphates, in the phytic acid-related natural mutants could be a reason for their negative pleiotropic effects[6].
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